Extracellular vesicles (EVs) and metabolic dysfunctions: interrelationship between metabolic syndrome (MetS) and obstructive sleep apnea (OSA)

MetS and OSA are two major syndromes with high penetration in the Western world leading to the increase of cardiovascular risks. We take into account two types of EVs, microparticles (MPs) and exosomes. The main goal is to predict MetS development and its interrelationship and penetration with OSA with into overt disease as well as define new therapeutic opportunities from the delivery of ‘specific’ vesicle subsets. Thus, the focal point of the project is EVs bringing novelty, and establishing possibly a selling point in view of concepts uniqueness. For disease outcome, the focus will be of common downstream consequences of MetS and OSA such as increased cardiovascular morbidity including peripheral vascular diseases and coronary artery disease.